Description

(S)-3,3,3-Trifluoropropane-1,2-Diamine Dihydrochloride CAS NO 909002-38-6 is a high-purity, chiral diamine building block featuring a trifluoromethyl group, offering unique steric and electronic properties for advanced molecular design. This compound is critical for introducing fluorine atoms and chiral centers into target molecules, significantly enhancing their metabolic stability, lipophilicity, and binding affinity. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for developing novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in creating advanced, fluorinated pesticides and herbicides with improved efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics & Bio-conjugates: Incorporated into peptide backbones to create metabolically stable analogs and diagnostic probes.
• Material Science: A building block for fluorinated polymers, dendrimers, and specialty coatings with tailored surface properties.
• Chemical Biology Probes: Utilized in the development of activity-based probes and molecular tools for studying enzyme mechanisms.

Basic Information

Product Name	(S)-3,3,3-Trifluoropropane-1,2-Diamine Dihydrochloride
CAS No.	909002-38-6
Molecular Formula	C3H8Cl2F3N2
Molecular Weight	209.01 g/mol
Synonyms	(S)-1,2-Diamino-3,3,3-trifluoropropane dihydrochloride; (S)-3,3,3-Trifluoro-1,2-propanediamine dihydrochloride; (S)-TFPA-2HCl; (S)-3,3,3-Trifluoropropane-1,2-diamine hydrochloride; (S)-1,2-Diamino-3,3,3-trifluoropropane hydrochloride; (S)-3-Amino-1,1,1-trifluoropropan-2-amine dihydrochloride; (S)-α,β-Diamino-β,β,β-trifluoroethane dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-3,3,3-Trifluoropropane-1,2-Diamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.