Description

Fmoc-6-Chloro L-Tryptophan CAS NO 908847-42-7 is a protected, halogenated derivative of the essential amino acid L-tryptophan, specifically engineered for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the pharmaceutical and biotechnology industries, enabling the precise incorporation of a modified tryptophan residue into complex peptide sequences. It is primarily utilized by research institutions, CROs/CDMOs, and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptides.
• Pharmaceutical Research & Development: Used to synthesize peptide-based drug candidates, where the 6-chloro modification can alter bioactivity, stability, and receptor binding affinity.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorescently labeled or affinity-tagged peptides for diagnostic and imaging applications.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemists to study the impact of halogenation at the tryptophan indole ring on peptide function and potency.
• Production of Non-Natural Amino Acid Libraries: A key component in combinatorial chemistry for generating diverse peptide libraries for high-throughput screening.

Basic Information

Product Name	Fmoc-6-Chloro L-Tryptophan
CAS No.	908847-42-7
Molecular Formula	C₂₆H₂₁ClN₂O₄
Molecular Weight	460.91 g/mol
Synonyms	Fmoc-6-Cl-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-6-chloro-L-tryptophan; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(6-chloro-1H-indol-3-yl)propanoic acid; Fmoc-6-chloro-L-Trp; Fmoc-6-chlorotryptophan; Nα-Fmoc-6-chloro-L-tryptophan; 6-Chloro-L-tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-Trp(6-Cl)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-6-Chloro L-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with the stringent requirements of pharmaceutical R&D and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere (e.g., nitrogen or argon) when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	-20° to -30° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.