Description

n-Fmoc-6-Methyl-L-Tryptophan CAS NO 908846-99-1 is a protected derivative of the non-proteinogenic amino acid 6-methyl-L-tryptophan, featuring an N-terminal 9-fluorenylmethoxycarbonyl (Fmoc) protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of the unique 6-methyltryptophan residue into complex peptide chains. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, diagnostic agents, and biochemical tools where precise structural modification is required to modulate biological activity, stability, and pharmacokinetic properties.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, sequential assembly of custom peptides.
• Pharmaceutical Research & Development: For the synthesis of peptide drug candidates containing the modified tryptophan side chain to enhance binding affinity, metabolic stability, or receptor selectivity.
• Bioconjugation & Probe Development: Used to introduce a fluorescent or reactive handle via the indole moiety for labeling proteins or creating molecular probes.
• Structure-Activity Relationship (SAR) Studies: Essential for investigating the role of tryptophan methylation in peptide-protein interactions and biological function.
• Production of Non-Ribosomal Peptide Mimetics: For the chemical synthesis of analogs of natural products and complex peptides that are not accessible through biological expression systems.

Basic Information

Product Name	n-Fmoc-6-Methyl-L-Tryptophan
CAS No.	908846-99-1
Molecular Formula	C₂₈H₂₆N₂O₄
Molecular Weight	454.52 g/mol
Synonyms	Fmoc-6-Me-Trp-OH; Fmoc-6-methyltryptophan; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-6-methyl-L-tryptophan; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(6-methyl-1H-indol-3-yl)propanoic acid; 6-Methyl-L-tryptophan, N-Fmoc derivative; Fmoc-6-methyl-L-Trp; N-α-Fmoc-6-methyl-L-tryptophan
EINECS	Contact for details

Quality Control

Our n-Fmoc-6-Methyl-L-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and spectroscopic identification. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research and cGMP-grade synthesis requirements. Specifications are designed to meet the high standards of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.