Description

4-(1-(tert-Butoxycarbonyl)Azetidin-3-Yl)Benzoic Acid is a high-purity, advanced pharmaceutical intermediate featuring a strategically protected azetidine ring. This compound is essential for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Protease Inhibitor Development: Used in research for creating inhibitors where the azetidine moiety acts as a core scaffold or a bioisostere.
• Peptidomimetic Chemistry: Serves as a constrained amino acid analog for constructing peptide-like molecules with enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Building Block for PROTACs: Utilized as a linker or component in the development of Proteolysis-Targeting Chimeras (PROTACs) and other bifunctional molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	4-(1-(tert-Butoxycarbonyl)Azetidin-3-Yl)Benzoic Acid
CAS No.	908334-10-1
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	4-(1-Boc-azetidin-3-yl)benzoic acid; 4-(1-[(tert-Butoxy)carbonyl]-3-azetidinyl)benzoic acid; 3-(4-Carboxyphenyl)-1-Boc-azetidine; 1-Boc-3-(4-carboxyphenyl)azetidine; 4-(1-(tert-Butoxycarbonyl)azetidin-3-yl)benzoic acid; tert-Butyl 3-(4-carboxyphenyl)azetidine-1-carboxylate; 908334-10-1; Boc-Azetidine-3-yl-benzoic Acid
EINECS	Contact for details

Quality Control

Our 4-(1-(tert-Butoxycarbonyl)Azetidin-3-Yl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.