Description

n-Boc-N’-(4-Cyanobenzyl)-2-L-Azetidinecarboxamide is a high-purity, protected azetidine derivative used as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications such as peptidomimetics and the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Scaffold: Used to introduce constrained, four-membered azetidine rings into peptide backbones to enhance metabolic stability and bioavailability.
• Protease Inhibitor Synthesis: Serves as a core structural element in the design and synthesis of novel protease inhibitors.
• Agrochemical Research: Employed as a building block for developing new crop protection agents with novel modes of action.
• Chemical Biology Probes: Utilized in the creation of labeled compounds and activity-based probes for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity advanced intermediates.

Basic Information

Product Name	n-Boc-N’-(4-Cyanobenzyl)-2-L-Azetidinecarboxamide
CAS No.	908259-42-7
Molecular Formula	C17H21N3O3
Molecular Weight	315.37 g/mol
Synonyms	1-[(4-Cyanophenyl)methyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-azetidinecarboxamide; (2S)-1-[(4-Cyanophenyl)methyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-azetidinecarboxamide; tert-Butyl N-[(2S)-1-[(4-cyanophenyl)methyl]-2-(aminocarbonyl)azetidin-3-yl]carbamate; Boc-Azetidine(2-CONH2)-(1-Cyanobenzyl); L-Azetidine-2-carboxamide, 1-[(4-cyanophenyl)methyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino]-; 908259-42-7; Boc-protected azetidine cyanobenzyl carboxamide
EINECS	Contact for details

Quality Control

Our n-Boc-N’-(4-Cyanobenzyl)-2-L-Azetidinecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with stringent specifications for research and development use. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.