Description

5-o-Methanesulfonate-2,3-o-Isopropylidene-2-C-Methyl-D-Ribonic-γ-Lactone is a high-purity, advanced pharmaceutical intermediate critical for the synthesis of complex nucleoside analogs and other bioactive molecules. Its value lies in its role as a versatile chiral building block, enabling precise stereochemical control in the development of antiviral and anticancer therapeutics. This compound is essential for R&D and production teams in the pharmaceutical, biotechnology, and fine chemical sectors seeking reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Antiviral Drug Development: Used in research and production of modified nucleosides targeting viral polymerases.
• Biochemical Research: Serves as a precursor for labeled compounds and probes in metabolic pathway studies.
• Carbohydrate Chemistry: A valuable substrate for the preparation of complex, selectively protected sugar derivatives.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of specialty chemicals requiring high stereochemical purity.
• Process Chemistry & Scale-Up: Supports route development and optimization from laboratory to pilot and commercial scale.

Basic Information

Product Name	5-o-Methanesulfonate-2,3-o-Isopropylidene-2-C-Methyl-D-Ribonic-γ-Lactone
CAS No.	908128-94-9
Molecular Formula	C11H18O7S
Molecular Weight	294.32 g/mol
Synonyms	2,3-O-Isopropylidene-2-C-methyl-5-O-(methylsulfonyl)-D-ribono-1,4-lactone; 2-C-Methyl-2,3-O-isopropylidene-5-O-methanesulfonyl-D-ribono-1,4-lactone; 5-O-Mesyl-2,3-O-isopropylidene-2-C-methyl-D-ribono-γ-lactone; 2,3-O-Isopropylidene-5-O-methanesulfonyl-2-C-methyl-D-ribono-1,4-lactone; 2-C-Methyl-2,3-O-(1-methylethylidene)-5-O-(methylsulfonyl)-D-ribono-1,4-lactone; D-Ribono-1,4-lactone, 2,3-O-(1-methylethylidene)-2-C-methyl-5-O-(methylsulfonyl)-; 908128-94-9
EINECS	Contact for details

Quality Control

Our 5-o-Methanesulfonate-2,3-o-Isopropylidene-2-C-Methyl-D-Ribonic-γ-Lactone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation upon exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.