Description

4-(6,6-Dimethyl-4-Oxo-3-(Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazol-1-Yl)-2-((1R,4R)-4-Hydroxycyclohexylamino)Benzamide is a sophisticated chiral benzamide derivative featuring a fused indazolone core and a trifluoromethyl group, representing a high-value advanced pharmaceutical intermediate. This compound is critical for research and development in medicinal chemistry, particularly for programs targeting complex disease pathways. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the research and synthesis of novel drug candidates, especially in oncology and metabolic disease research.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Process Chemistry Development: Employed in the development and scale-up of synthetic routes for complex target molecules under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Acts as a high-purity analytical standard for method development and quality control in API manufacturing.
• Biochemical Probe Development: Utilized in the design and creation of chemical probes for investigating specific biological targets and pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	4-(6,6-Dimethyl-4-Oxo-3-(Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazol-1-Yl)-2-((1R,4R)-4-Hydroxycyclohexylamino)Benzamide
CAS No.	908112-43-6
Molecular Formula	C23H27F3N4O3
Molecular Weight	464.48 g/mol
Synonyms	4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-[(1R,4R)-4-hydroxycyclohexylamino]benzamide; (1R,4R)-4-({4-[(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)]-2-carbamoylphenyl}amino)cyclohexanol; Benzamide, 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-[(1R,4R)-4-hydroxycyclohexylamino]-; CAS 908112-43-6
EINECS	Contact for details

Quality Control

Our production of 4-(6,6-Dimethyl-4-Oxo-3-(Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazol-1-Yl)-2-((1R,4R)-4-Hydroxycyclohexylamino)Benzamide adheres to stringent quality management systems, ensuring batch-to-batch consistency and traceability. All materials are subjected to comprehensive analytical testing, including chiral purity verification, to meet the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.