Description

5-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-1-Ylamine Hydrochloride is a high-purity, fluorinated tetralin-based amine salt, a key building block in advanced organic synthesis. This compound is valued for its role as a versatile chiral intermediate, enabling the construction of complex molecular architectures with high stereochemical control. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for developing novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of central nervous system (CNS) active compounds, serotonin/norepinephrine reuptake inhibitors, and other therapeutic agents.
• Agrochemical Research: Serves as a precursor in developing novel fluorinated pesticides and herbicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand & Catalyst Development: Used in the preparation of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of advanced polymers and liquid crystals where the tetralin scaffold imparts specific rigidity and optical properties.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, particularly in fluorination and hydrogenation reactions.

Basic Information

Product Name	5-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-1-Ylamine Hydrochloride
CAS No.	907973-43-7
Molecular Formula	C₁₀H₁₃ClFN
Molecular Weight	201.67 g/mol
Synonyms	1-Amino-5-fluoro-1,2,3,4-tetrahydronaphthalene hydrochloride; 5-Fluoro-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride; 5-Fluoro-1-amino-1,2,3,4-tetrahydronaphthalene HCl; 5-Fluoro-1-tetralinamine hydrochloride; (5-Fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)amine hydrochloride; 5-Fluoro-α-tetralinamine hydrochloride; 907973-43-7
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-1-Ylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and IR spectroscopy. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.