Description

1-(2,2,2-Trifluoro-Ethyl)-Piperazin-2-One is a high-value, fluorinated piperazinone derivative, a key building block in modern synthetic chemistry. Its trifluoroethyl group imparts unique physicochemical properties, making it a critical intermediate for developing advanced materials and active pharmaceutical ingredients (APIs). This compound is essential for research and production in pharmaceutical development, agrochemical synthesis, and specialty chemical manufacturing, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A crucial synthon for the research and development of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine moiety enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with specific thermal and chemical resistance properties.
• Chemical Biology Probes: Utilized as a building block for developing molecular probes and diagnostic agents in life sciences research.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring the incorporation of a trifluoroethyl-piperazinone motif.

Basic Information

Product Name	1-(2,2,2-Trifluoro-Ethyl)-Piperazin-2-One
CAS No.	907972-20-7
Molecular Formula	C7H11F3N2O
Molecular Weight	196.17 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)piperazin-2-one; 2-Piperazinone, 1-(2,2,2-trifluoroethyl)-; 1-(Trifluoroethyl)-2-piperazinone; 1-(2,2,2-Trifluoroethyl)-2-piperazinone; 1-(2,2,2-Trifluoroethyl)piperazin-2-one; 907972-20-7; TFE-Piperazinone; Trifluoroethyl piperazinone
EINECS	Contact for details

Quality Control

Our 1-(2,2,2-Trifluoro-Ethyl)-Piperazin-2-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids, strong bases, and strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.