Description

tert-Butyl (3R,4S)-4-Amino-3-Fluoropiperidine-1-Carboxylate is a high-purity, stereochemically defined fluorinated piperidine derivative, serving as a critical chiral building block in modern organic synthesis. Its value lies in providing a structurally rigid, functionalized scaffold for constructing complex molecules with precise three-dimensional control. This advanced intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients where fluorine substitution and specific stereochemistry are key to biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) drugs, kinase inhibitors, and antiviral agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom and amino group can enhance bioactivity and environmental persistence.
• Peptidomimetics & PROTACs: Serves as a constrained dipeptide isostere or a linker component in Proteolysis-Targeting Chimeras (PROTACs) and other bifunctional molecules.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying enzyme mechanisms and receptor interactions.
• Asymmetric Catalysis Ligand Precursor: Can be utilized to develop novel chiral ligands and organocatalysts for enantioselective transformations.
• Material Science Research: Investigated as a monomer or functional additive for creating specialty polymers with unique properties.

Basic Information

Product Name	tert-Butyl (3R,4S)-4-Amino-3-Fluoropiperidine-1-Carboxylate
CAS No.	907544-17-6
Molecular Formula	C10H19FN2O2
Molecular Weight	218.27 g/mol
Synonyms	1-Boc-4-amino-3-fluoropiperidine (3R,4S)-isomer; (3R,4S)-1-(tert-Butoxycarbonyl)-4-amino-3-fluoropiperidine; tert-Butyl (3R,4S)-4-amino-3-fluoro-1-piperidinecarboxylate; (3R,4S)-4-Amino-3-fluoro-1-Boc-piperidine; N-Boc-(3R,4S)-4-Amino-3-fluoropiperidine; (3R,4S)-3-Fluoro-4-aminopiperidine-1-carboxylic acid tert-butyl ester; Boc-AminofluoroPiperidine (3R,4S)
EINECS	Contact for details

Quality Control

Our tert-Butyl (3R,4S)-4-Amino-3-Fluoropiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric and diastereomeric purity, to meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.