Description

tert-Butyl ((1R,2S)-2-(4-Bromophenyl)cyclopropyl)carbamate is a high-purity, chiral cyclopropane derivative and a key protected intermediate in advanced organic synthesis. This compound matters for its precise stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) with specific biological activity. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel therapeutic agents, particularly in the areas of antiviral and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of complex drug candidates, especially in antiviral and CNS-targeted therapies.
• Protease Inhibitor Research: Used in the development of protease inhibitors, leveraging the cyclopropane scaffold for conformational constraint.
• Asymmetric Synthesis: Serves as a starting material or intermediate in stereoselective synthesis routes to create enantiomerically pure compounds.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Peptidomimetics: The carbamate-protected amine and rigid cyclopropane structure make it valuable for designing peptide mimics.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects.

Basic Information

Product Name	tert-Butyl ((1R,2S)-2-(4-Bromophenyl)cyclopropyl)carbamate
CAS No.	907196-03-6
Molecular Formula	C14H18BrNO2
Molecular Weight	312.20 g/mol
Synonyms	(1R,2S)-2-(4-Bromophenyl)cyclopropanamine, N-Boc derivative; BOC-(1R,2S)-2-(4-Bromophenyl)cyclopropylamine; tert-Butyl (1R,2S)-2-(4-bromophenyl)cyclopropylcarbamate; N-Boc-trans-2-(4-bromophenyl)cyclopropylamine; (1R,2S)-N-(tert-Butoxycarbonyl)-2-(4-bromophenyl)cyclopropanamine; BOC-Protected (1R,2S)-2-(4-Bromophenyl)cyclopropylamine; 1-Boc-amino-2-(4-bromophenyl)cyclopropane (trans, (1R,2S)); 907196-03-6
EINECS	Contact for details

Quality Control

Our tert-Butyl ((1R,2S)-2-(4-Bromophenyl)cyclopropyl)carbamate is manufactured under strict quality control protocols to ensure high chiral purity and chemical integrity, suitable for demanding pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of global regulatory standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.