Description

2-[4-Bromo-3-(Hydroxymethyl)Phenoxy]-Benzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its distinct brominated aromatic ether structure. This compound is of significant commercial importance for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular scaffolds. It is primarily sought after by research institutions and manufacturers in the global pharmaceutical and agrochemical industries for developing new chemical entities and fine-tuning product efficacy.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drugs, particularly those targeting central nervous system (CNS) disorders and inflammatory conditions.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, leveraging its phenoxy-benzonitrile core for biological activity.
• Liquid Crystal Material Precursor: Serves as a sophisticated monomer or intermediate in the production of high-performance liquid crystals for display technologies.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and other catalytic processes to construct complex aromatic systems in academic and industrial R&D.
• Polymer Modifier: Acts as a functional monomer to introduce bromine and cyano groups into polymer chains, enhancing flame retardancy and thermal stability.

Basic Information

Item	Details
Product Name	2-[4-Bromo-3-(Hydroxymethyl)Phenoxy]-Benzonitrile
CAS No.	906673-58-3
Molecular Formula	C14H10BrNO2
Molecular Weight	304.14 g/mol
Synonyms	4-Bromo-3-(hydroxymethyl)phenyl 2-cyanophenyl ether; 2-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile; Benzonitrile, 2-[4-bromo-3-(hydroxymethyl)phenoxy]-; 2-Cyano-4'-bromo-3'-hydroxymethyldiphenyl ether; 4'-Bromo-3'-hydroxymethyl-2-cyanodiphenyl ether; 2-(4-Bromo-3-hydroxymethyl-phenoxy)-benzonitrile; (4-Bromo-3-hydroxymethyl-phenoxy)-o-cyanobenzene
EINECS	Contact for details

Quality Control

Our production of 2-[4-Bromo-3-(Hydroxymethyl)Phenoxy]-Benzonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. Every lot is subjected to comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity, purity, and impurity profiles. We provide full traceability and Certificates of Analysis (COA) are available upon request, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.