Description

Methyl 4-(4-Boc-1-Piperazinyl)-3-Chlorobenzoate is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine ring and a benzoate ester moiety. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for potential drug candidates under Good Manufacturing Practice (GMP) guidelines.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the synthesis of heterobifunctional molecules designed for targeted protein degradation.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	Methyl 4-(4-Boc-1-Piperazinyl)-3-Chlorobenzoate
CAS No.	906559-46-4
Molecular Formula	C17H23ClN2O4
Molecular Weight	354.83 g/mol
Synonyms	Methyl 3-chloro-4-(4-(tert-butoxycarbonyl)piperazin-1-yl)benzoate; 3-Chloro-4-[4-(tert-butoxycarbonyl)-1-piperazinyl]benzoic Acid Methyl Ester; 4-(4-Boc-piperazin-1-yl)-3-chloro-benzoic acid methyl ester; Methyl 4-(N-Boc-piperazinyl)-3-chlorobenzoate; 906559-46-4; 1-Boc-4-(2-chloro-4-(methoxycarbonyl)phenyl)piperazine; Benzoic acid, 3-chloro-4-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 4-(4-Boc-1-Piperazinyl)-3-Chlorobenzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or development specifications. Our quality commitment supports applications requiring high-purity intermediates for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.