Description

2'-Des(1-Hydroxy-1-Methylethyl)-2'-Methycarboxy Montelukast Hydrochloride is a key pharmaceutical intermediate in the synthesis of Montelukast, a potent leukotriene receptor antagonist. This compound is critical for ensuring the purity, efficacy, and regulatory compliance of the final active pharmaceutical ingredient (API). It is primarily required by pharmaceutical manufacturers and advanced research facilities engaged in the development and production of respiratory therapeutics, particularly asthma and allergy medications.

Application

• Primary Intermediate in the synthesis of Montelukast Sodium, the active ingredient in leading asthma and allergy medications.
• Research & Development for novel leukotriene pathway inhibitors and related respiratory disease treatments.
• Process Chemistry optimization and scale-up activities within pharmaceutical manufacturing.
• Reference Standard for analytical method development and quality control testing in API production.
• Generic Drug Manufacturing for companies producing bioequivalent versions of Montelukast-based therapies.

Basic Information

Product Name	2'-Des(1-Hydroxy-1-Methylethyl)-2'-Methycarboxy Montelukast Hydrochloride
CAS No.	906107-37-7
Molecular Formula	C35H36ClNO4S
Molecular Weight	602.18 g/mol
Synonyms	Montelukast Impurity; Montelukast Intermediate; 2'-Des(1-Hydroxy-1-methylethyl)-2'-methoxycarbonyl Montelukast HCl; 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic Acid Hydrochloride (related); Des-Hydroxy-Tert-Butyl Montelukast Carboxylic Acid Hydrochloride; (R)-2-(1-((1-(3-(2-(7-Chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)thio)methyl)cyclopropaneacetic Acid Hydrochloride (alternative IUPAC); MK-0476 Intermediate
EINECS	Contact for details

Quality Control

Our 2'-Des(1-Hydroxy-1-Methylethyl)-2'-Methycarboxy Montelukast Hydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for pharmaceutical intermediate use. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.