Description

Deshydroxy Bicalutamide is a key pharmaceutical intermediate and reference standard used in the development and quality control of active pharmaceutical ingredients (APIs). This compound is of significant interest in research and manufacturing due to its structural relationship to Bicalutamide, a well-established anti-androgen medication. It serves as a critical building block for pharmaceutical chemists and quality assurance professionals in the life sciences sector, enabling advanced synthesis and analytical verification processes.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of advanced drug candidates and related steroid receptor modulators.
• Analytical Reference Standard: Used for method development, validation, and quality control (QC) testing in pharmaceutical laboratories to ensure product purity and identity.
• Research & Development: Employed in biochemical and pharmacological research to study structure-activity relationships (SAR) and metabolic pathways.
• Impurity Standard: Serves as a certified reference material for identifying and quantifying potential impurities or degradation products in Bicalutamide API batches.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for complex organic molecules within GMP environments.

Basic Information

Product Name	Deshydroxy Bicalutamide
CAS No.	906008-94-4
Molecular Formula	C18H14F4N2O4S
Molecular Weight	430.38 g/mol
Synonyms	N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide; Deshydroxy Bicalutamide; Bicalutamide Deshydroxy Impurity; Bicalutamide Related Compound; Bicalutamide Impurity; Bicalutamide Intermediate; UNII-7VJ3151K1P
EINECS	Contact for details

Quality Control

Our Deshydroxy Bicalutamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with cGMP guidelines for pharmaceutical intermediates. Specifications are aligned with ICH Q3A/B guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.