Description

4H-Inden-4-One, Ctahydro-7A-Methyl-1-[(1S,2E,4S)-1,4,5-Trimethyl-5-[(Trimethylsilyl)Oxy]-2-Hexen-1-Yl]-, (1R,3Ar,7Ar)- is a high-purity, complex organic intermediate featuring a unique indanone core with a trimethylsilyl-protected hydroxyl group. This compound is of significant value for advanced pharmaceutical research and fine chemical synthesis, serving as a critical chiral building block. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex stereochemistry.
• Asymmetric Synthesis: Utilized as a sophisticated starting material or intermediate in catalytic asymmetric reactions to introduce specific stereocenters.
• Natural Product Synthesis: Serves as a building block in the total synthesis of complex natural products with indane or related structural motifs.
• Agrochemical Research: Employed in the discovery and development of new generation pesticides and herbicides where specific stereoisomers are required for optimal activity.
• Material Science Precursor: Potential use in the synthesis of advanced organic materials, such as ligands for catalysts or components for organic electronics.
• Process Chemistry Development: Used for scaling up synthetic routes and optimizing manufacturing processes for target molecules in a GMP environment.

Basic Information

Product Name	4H-Inden-4-One, Ctahydro-7A-Methyl-1-[(1S,2E,4S)-1,4,5-Trimethyl-5-[(Trimethylsilyl)Oxy]-2-Hexen-1-Yl]-, (1R,3Ar,7Ar)-
CAS No.	905932-25-4
Molecular Formula	C22H40O2Si
Molecular Weight	364.6 g/mol
Synonyms	(1R,3aR,7aR)-1-[(1S,2E,4S)-1,4,5-Trimethyl-5-[(trimethylsilyl)oxy]-2-hexen-1-yl]octahydro-7a-methyl-4H-inden-4-one; 4H-Inden-4-one, octahydro-7a-methyl-1-[(1S,2E,4S)-1,4,5-trimethyl-5-[(trimethylsilyl)oxy]-2-hexen-1-yl]-, (1R,3aR,7aR)-; TMS-protected indanone derivative; Chiral indanone-TMS ether; Advanced pharmaceutical building block.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity intermediates. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to strict quality management protocols suitable for cGMP and ISO environments to ensure supply reliability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.