Description

n-[(2R)]-1-Amino-3-(4-Nitrophenyl)Propyl]-1,2-Cyclohexanediamine Trihydrochloride is a high-purity, chiral organic compound primarily utilized as a critical intermediate in advanced pharmaceutical synthesis. Its value lies in its specific stereochemistry and functional groups, which make it an essential building block for developing targeted active pharmaceutical ingredients (APIs). This compound is particularly relevant for research and production teams in the pharmaceutical, biotechnology, and fine chemical sectors, where precise molecular architecture is paramount for drug efficacy and safety.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug candidates.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring a defined (R)-configuration.
• Chemical Biology Research: Used as a precursor or ligand in the study of biological pathways and enzyme inhibition assays due to its amine-functionalized structure.
• Asymmetric Catalysis: Can be employed as a chiral auxiliary or ligand precursor in asymmetric synthesis to induce stereoselectivity in chemical reactions.
• Fine Chemical Production: Integral in the manufacture of high-value, specialty chemicals where optical purity and specific molecular geometry are required.

Basic Information

Product Name	n-[(2R)]-1-Amino-3-(4-Nitrophenyl)Propyl]-1,2-Cyclohexanediamine Trihydrochloride
CAS No.	905825-54-9
Molecular Formula	C15H27Cl3N4O2
Molecular Weight	401.76 g/mol
Synonyms	(1R,2R)-2-[[(2R)-1-Amino-3-(4-nitrophenyl)propyl]amino]cyclohexanamine trihydrochloride; (1R,2R)-N1-[(1R)-1-Amino-3-(4-nitrophenyl)propyl]cyclohexane-1,2-diamine trihydrochloride; (1R,2R)-2-{[(2R)-1-Amino-3-(4-nitrophenyl)propyl]amino}cyclohexanamine trihydrochloride; UNII-9Q2I2P8H5T; 9Q2I2P8H5T; (R,R)-2-((R)-1-Amino-3-(4-nitrophenyl)propylamino)cyclohexylamine trihydrochloride
EINECS	Contact for details

Quality Control

Our n-[(2R)]-1-Amino-3-(4-Nitrophenyl)Propyl]-1,2-Cyclohexanediamine Trihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral content, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.