Description

Morphinan-17-Carboxylic Acid, 3,14-Bis(Acetyloxy)-4,5-Epoxy-6-Oxo-, Ethyl Ester, (5α)- is a high-purity, advanced pharmaceutical intermediate of significant importance in modern medicinal chemistry. This compound serves as a critical synthetic precursor for the development of novel opioid receptor modulators and other specialized active pharmaceutical ingredients (APIs). It is primarily required by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the synthesis of complex therapeutic agents targeting the central nervous system.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of potent opioid analgesics and their derivatives.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new compounds with targeted receptor affinity and reduced side-effect profiles.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Development: Employed in scaling up and optimizing synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Preclinical Studies: Utilized in the preparation of compounds for pharmacological evaluation and toxicological assessment.

Basic Information

Product Name	Morphinan-17-Carboxylic Acid, 3,14-Bis(Acetyloxy)-4,5-Epoxy-6-Oxo-, Ethyl Ester, (5α)-
CAS No.	905817-72-3
Molecular Formula	C25H27NO8
Molecular Weight	469.48 g/mol
Synonyms	Ethyl 3,14-Diacetoxy-4,5-epoxy-6-oxomorphinan-17-carboxylate; (5α)-3,14-Bis(acetyloxy)-4,5-epoxy-6-oxomorphinan-17-carboxylic Acid Ethyl Ester; 3,14-Diacetyloxy-4,5α-epoxy-6-oxo-17-ethoxycarbonylmorphinan; 17-Carbethoxy-3,14-diacetoxy-4,5α-epoxy-6-oxomorphinan; O3,O14-Diacetyl-6-oxo-17-ethoxycarbonyl-4,5α-epoxymorphinan; A key oxymorphone/oxymorphone derivative intermediate.
EINECS	Contact for details

Quality Control

Our Morphinan-17-Carboxylic Acid, 3,14-Bis(Acetyloxy)-4,5-Epoxy-6-Oxo-, Ethyl Ester, (5α)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.