Description

(S)-1-(5-Fluoro-Pyrimidin-2-Yl)-Ethylamine CAS NO 905587-29-3 is a high-purity chiral amine building block, specifically the (S)-enantiomer, featuring a fluorinated pyrimidine core. This compound is of significant value in pharmaceutical research and development, serving as a critical intermediate for the synthesis of targeted small molecule drugs. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients with enhanced selectivity and potency.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of antiviral, anticancer, and central nervous system (CNS) active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides that require specific stereochemistry for optimal activity.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Bioconjugation and Probe Synthesis: The amine functionality allows for conjugation to fluorescent dyes, biotin, or other reporter molecules for biochemical research tools.
• Peptidomimetics and PROTACs: Incorporated into the design of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) for targeted protein degradation.
• Material Science Research: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and advanced organic materials.

Basic Information

Product Name	(S)-1-(5-Fluoro-Pyrimidin-2-Yl)-Ethylamine
CAS No.	905587-29-3
Molecular Formula	C6H8FN3
Molecular Weight	141.15 g/mol
Synonyms	(S)-1-(5-Fluoropyrimidin-2-yl)ethan-1-amine; (S)-α-Methyl-5-fluoropyrimidine-2-methanamine; (S)-2-(1-Aminoethyl)-5-fluoropyrimidine; (S)-5-Fluoro-2-(1-aminoethyl)pyrimidine; (S)-1-(5-Fluoro-2-pyrimidinyl)ethylamine; (S)-Enantiomer of 1-(5-Fluoropyrimidin-2-yl)ethylamine; 905587-29-3; (S)-FPEMA
EINECS	Contact for details

Quality Control

Our (S)-1-(5-Fluoro-Pyrimidin-2-Yl)-Ethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with high-purity standards for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.