Description

(1S,2S,4R)-4-[4-[[(1S)-2,3-Dihydro-1H-Inden-1-Yl]Amino]-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl]-2-Hydroxy-Cyclopentanemethanol is a high-purity, advanced pharmaceutical intermediate with a complex stereospecific structure. This compound is of critical importance for the research and development of targeted therapeutic agents, particularly in oncology. It is primarily needed by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers engaged in the synthesis of novel drug candidates.

Application

• Key Intermediate in Kinase Inhibitor Synthesis: Serves as a crucial building block for the development of potent and selective kinase inhibitors targeting various cancer pathways.
• Pharmaceutical Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Preclinical and Clinical Trial Material Production: Supplied for the cGMP-compliant manufacture of active pharmaceutical ingredients (APIs) for investigational new drugs (INDs).
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control testing.
• Custom Synthesis Projects: Utilized by fine chemical companies for bespoke synthesis services for biotechnology and pharmaceutical clients.

Basic Information

Product Name	(1S,2S,4R)-4-[4-[[(1S)-2,3-Dihydro-1H-Inden-1-Yl]Amino]-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl]-2-Hydroxy-Cyclopentanemethanol
CAS No.	905580-90-7
Molecular Formula	C21H24N4O2
Molecular Weight	364.44 g/mol
Synonyms	4-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-7-[(1S,2S,4R)-4-(hydroxymethyl)-2-hydroxycyclopentyl]-7H-pyrrolo[2,3-d]pyrimidine; (1S,2S,4R)-rel-4-[4-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentanemethanol; Crizotinib Intermediate; Crizotinib Related Compound; PF-02341066 Intermediate; ALK Inhibitor Intermediate; Xalkori Intermediate; Cyclopentanemethanol, 4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxy-, (1S,2S,4R)-
EINECS	Contact for details

Quality Control

Our (1S,2S,4R)-4-[4-[[(1S)-2,3-Dihydro-1H-Inden-1-Yl]Amino]-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl]-2-Hydroxy-Cyclopentanemethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR, and MS for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We can support development with research-grade to cGMP-grade material as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C) or as indicated on the certificate of analysis. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.