Description

n-[(1S)-2,3-Dihydro-1H-Inden-1-Yl]-1H-Pyrrolo[2,3-D]Pyrimidin-4-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Kinase Inhibitor Development: Serves as a core scaffold in the research and development of potent and selective kinase inhibitors, a major class of oncology and anti-inflammatory drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug candidate potency, selectivity, and pharmacokinetic properties.
• Biochemical Probe Synthesis: Employed in creating chemical probes for studying specific biological pathways and target validation in cellular assays.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis and scale-up projects under cGMP or research-grade conditions.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	n-[(1S)-2,3-Dihydro-1H-Inden-1-Yl]-1H-Pyrrolo[2,3-D]Pyrimidin-4-Amine
CAS No.	905580-86-1
Molecular Formula	C₁₅H₁₄N₄
Molecular Weight	250.30 g/mol
Synonyms	(S)-N-(2,3-Dihydro-1H-inden-1-yl)-1H-pyrrolo[2,3-d]pyrimidin-4-amine; 1H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[(1S)-2,3-dihydro-1H-inden-1-yl]-; UNII-9G2H6F8Q7K; 9G2H6F8Q7K; BDBM50111271; CHEMBL3185225; AKOS015915889; (S)-N-(2,3-Dihydro-1H-inden-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
EINECS	Contact for details

Quality Control

Our n-[(1S)-2,3-Dihydro-1H-Inden-1-Yl]-1H-Pyrrolo[2,3-D]Pyrimidin-4-Amine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and development specifications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided for every shipment to guarantee identity, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.