Description

(1’S,2S)-2-(2’-Tosyl-1’,2’-Dihydroxyethyl)-6-Fluorochromane is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for enabling the synthesis of complex, optically active drug molecules, particularly in the development of novel therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs) for clinical trials and commercial production.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the production of complex, fluorinated active pharmaceutical ingredients (APIs).
• Chiral Synthesis: Utilized in asymmetric synthesis routes to introduce specific stereocenters essential for biological activity in target drug molecules.
• Research & Development (R&D): Employed in medicinal chemistry for the discovery and optimization of new drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Process Chemistry & Scale-Up: Used in process development and optimization for the commercial-scale manufacturing of fluorinated chromane-based pharmaceuticals.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs producing clinical trial materials and commercial APIs for global pharmaceutical clients.

Basic Information

Product Name	(1’S,2S)-2-(2’-Tosyl-1’,2’-Dihydroxyethyl)-6-Fluorochromane
CAS No.	905454-58-2
Molecular Formula	C24H25FO6S
Molecular Weight	460.52 g/mol
Synonyms	(1'S,2S)-2-[2'-(4-Methylphenylsulfonyl)-1',2'-dihydroxyethyl]-6-fluorochromane; 6-Fluoro-2-[(1S,2S)-1-hydroxy-2-[(4-methylphenyl)sulfonyl]oxy]ethyl]chroman; (1'S,2S)-2-(2'-Tosyl-1',2'-dihydroxyethyl)-6-fluorochroman; 6-Fluorochroman-2-yl Tosyl Dihydroxyethyl Derivative (S,S-isomer); Fluorinated Chromane Tosylate Diol Intermediate; (S,S)-Tosyl Dihydroxyethyl Fluorochromane; Pharmaceutical Intermediate 905454-58-2
EINECS	Contact for details

Quality Control

Every batch of (1’S,2S)-2-(2’-Tosyl-1’,2’-Dihydroxyethyl)-6-Fluorochromane is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral purity verification, to ensure compliance with stringent industry standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA), detailing identity, purity, and impurity profiles as determined by HPLC, NMR, and MS, is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.