Description

(1S)-1-[(2R)-6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Yl]-1,2-Ethanediol 2-(4-Methylbenzenesulfonate) CAS NO 905454-52-6 is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical industry engaged in the development and production of complex therapeutic agents, particularly those targeting central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Neurological Drug Research: Key building block in the development of novel therapeutics for central nervous system (CNS) disorders.
• Process Chemistry: Used in route scouting and optimization for scalable, GMP-compliant manufacturing processes.
• Asymmetric Synthesis: Serves as a precursor in catalytic asymmetric transformations to construct complex molecular architectures.
• Analytical Reference Standard: Utilized as a high-purity standard for method development and quality control in analytical laboratories.
• Preclinical Development: Employed in the synthesis of candidate compounds for pharmacological and toxicological studies.

Basic Information

Product Name	(1S)-1-[(2R)-6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Yl]-1,2-Ethanediol 2-(4-Methylbenzenesulfonate)
CAS No.	905454-52-6
Molecular Formula	C18H19FO5S
Molecular Weight	366.40 g/mol
Synonyms	(1S,2R)-6-Fluoro-2-(2-hydroxyethyl)chroman-2-yl 4-methylbenzenesulfonate; (1S,2R)-6-Fluoro-2-(2-hydroxyethyl)chroman-2-yl tosylate; 6-Fluoro-2-(2-hydroxyethyl)chroman-2-yl p-toluenesulfonate (stereospecific); (1S,2R)-2-(2-Hydroxyethyl)-6-fluoro-3,4-dihydro-2H-chromen-2-yl 4-methylbenzenesulfonate; Fluorinated Chroman Tosylate Intermediate; Chiral Benzopyran Tosylate Ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (1S)-1-[(2R)-6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Yl]-1,2-Ethanediol 2-(4-Methylbenzenesulfonate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.