Description

2-Isobutyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole is a high-value organoboron building block, specifically a thiazole-substituted boronic ester, essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by pharmaceutical, agrochemical, and advanced materials researchers for the efficient synthesis of novel thiazole-containing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting thiazole-based heterocycles.
• Agrochemical Synthesis: Used in the research and development of new pesticides, herbicides, and fungicides that incorporate the thiazole moiety.
• Material Science Research: Enables the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge-transport materials, through controlled polymerization or functionalization.
• Chemical Biology & Probe Development: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes for studying biological systems.
• Academic & Contract Research: A vital reagent for methodology development and complex molecule synthesis in university and CRO (Contract Research Organization) laboratories.
• Ligand & Catalyst Preparation: Used to synthesize novel ligands or metal-organic frameworks (MOFs) with tailored properties for catalysis.

Basic Information

Product Name	2-Isobutyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole
CAS No.	905300-74-5
Molecular Formula	C13H22BNO2S
Molecular Weight	267.20 g/mol
Synonyms	2-(2-Isobutylthiazol-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-isobutylthiazole; 2-Isobutylthiazole-5-boronic acid pinacol ester; 2-Isobutyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole; Thiazole-5-boronic acid, 2-isobutyl-, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Isobutyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP (current Good Manufacturing Practice) standards for advanced intermediates and ensure compliance with relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.