Description

(1S,2S)-trans-2-Amino-1,2-Dihydro-1-Naphthol Hydrochloride is a high-purity chiral intermediate and building block of significant importance in advanced organic synthesis. Its defined stereochemistry makes it a critical precursor for the development of enantiomerically pure pharmaceuticals and fine chemicals. This compound is primarily needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active compounds and catalysts.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug research.
• Asymmetric Catalyst Ligand Precursor: Used in the development and manufacture of chiral ligands for asymmetric hydrogenation and other stereoselective transformations.
• Agrochemical Synthesis: Intermediate in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Serves as a starting material for complex specialty chemicals, dyes, and advanced materials requiring specific stereochemistry.
• Academic & Industrial Research: A valuable reagent for methodological development in organic chemistry and for studying structure-activity relationships (SAR).
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in regulated environments.

Basic Information

Product Name	(1S,2S)-trans-2-Amino-1,2-Dihydro-1-Naphthol Hydrochloride
CAS No.	904930-22-9
Molecular Formula	C₁₀H₁₂ClNO
Molecular Weight	197.66 g/mol
Synonyms	(1S,2S)-2-Amino-1,2-dihydro-1-naphthol hydrochloride; (1S,2S)-1-Amino-2-hydroxy-1,2-dihydronaphthalene hydrochloride; trans-(1S,2S)-2-Amino-1,2-dihydronaphthalen-1-ol hydrochloride; (1S,2S)-1,2-Dihydro-1-hydroxy-2-naphthylamine hydrochloride; (1S,2S)-1,2-Dihydro-2-amino-1-naphthol hydrochloride; (1S,2S)-2-Amino-1-naphthol hydrochloride (dihydro); trans-2-Amino-1,2-dihydro-1-naphthol HCl (enantiomer)
EINECS	Contact for details

Quality Control

Our (1S,2S)-trans-2-Amino-1,2-Dihydro-1-Naphthol Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity, chemical purity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and light-sensitive nature, the container should be kept in a desiccated environment and handled under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and moisture uptake. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.