Description

n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(2S)-2-Pyrrolidinylmethyl]- Thiourea is a high-purity, chiral thiourea derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a sophisticated organocatalyst and a critical building block for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions and chemical manufacturers specializing in asymmetric synthesis, medicinal chemistry, and the production of high-value specialty compounds.

Application

• Asymmetric Organocatalysis: Employed as a chiral hydrogen-bond donor catalyst in enantioselective reactions, such as Michael additions and aldol reactions.
• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new therapeutic agents.
• Ligand Synthesis: Used in the preparation of specialized ligands for metal-catalyzed processes.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Fine Chemical Production: Integral to the multi-step synthesis of complex, high-value specialty chemicals.
• Academic & Industrial R&D: A critical reagent for methodological development in synthetic organic chemistry laboratories.

Basic Information

Product Name	n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(2S)-2-Pyrrolidinylmethyl]- Thiourea
CAS No.	904928-30-9
Molecular Formula	C₁₄H₁₃F₆N₃S
Molecular Weight	369.33 g/mol
Synonyms	1-[3,5-Bis(trifluoromethyl)phenyl]-3-[(2S)-2-pyrrolidinylmethyl]thiourea; (S)-1-(3,5-Bis(trifluoromethyl)phenyl)-3-(pyrrolidin-2-ylmethyl)thiourea; N-(3,5-Bis(trifluoromethyl)phenyl)-N'-((S)-pyrrolidin-2-ylmethyl)thiourea; Chiral Thiourea Organocatalyst; (S)-2-[[[3,5-Bis(trifluoromethyl)phenyl]amino]thiocarbonyl]aminomethyl]pyrrolidine; BTFMP-Thiourea Catalyst; (S)-Pyrrolidine Thiourea Derivative
EINECS	Contact for details

Quality Control

Our production of n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(2S)-2-Pyrrolidinylmethyl]- Thiourea adheres to stringent quality protocols suitable for research and pharmaceutical applications. Each batch is characterized and tested to ensure high chiral purity and chemical identity. Certificates of Analysis (COA) are provided, detailing specifications for assay, enantiomeric excess, and impurity profiles. Our quality management system supports compliance with cGMP and ISO standards for reliable, batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic; therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent moisture absorption and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.