Description

2-Thiophen-2-Yl-2,3,4,5-Tetrahydro-1H-Benzo[B][1,4]Diazepine CAS NO 904813-50-9 is a high-purity, advanced pharmaceutical intermediate belonging to the benzodiazepine class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key building block in the research and development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel benzodiazepine-based drug candidates targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for the development and scale-up of proprietary synthetic routes for client APIs.
• Academic Research: Used in university and institutional laboratories for studying heterocyclic chemistry, reaction mechanisms, and new synthetic methodologies.
• Reference Standard: Suitable for use as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	2-Thiophen-2-Yl-2,3,4,5-Tetrahydro-1H-Benzo[B][1,4]Diazepine
CAS No.	904813-50-9
Molecular Formula	C15H14N2S
Molecular Weight	254.35 g/mol
Synonyms	2-(Thiophen-2-yl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine; 2-(2-Thienyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine; 1,4-Benzodiazepine, 2,3,4,5-tetrahydro-2-(2-thienyl)-; Benzo[b][1,4]diazepine, 2,3,4,5-tetrahydro-2-(2-thienyl)-; 904813-50-9
EINECS	Contact for details

Quality Control

Our 2-Thiophen-2-Yl-2,3,4,5-Tetrahydro-1H-Benzo[B][1,4]Diazepine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and good laboratory practice (GLP) standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.