Description

(1S,2R)-cis-2-(Boc-Amino)-1,2,3,4-Tetrahydro-1-Naphthol is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic utility. Its core value lies in its stereochemically defined structure, which is essential for constructing complex molecules with precise biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing focused libraries of compounds for structure-activity relationship (SAR) studies.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for potential new chemical entities (NCEs).
• Peptidomimetics & Bioactive Molecule Synthesis: The Boc-protected amino and tetralin-derived alcohol functionalities make it suitable for synthesizing constrained peptide analogs and other bioactive molecules.

Basic Information

Product Name	(1S,2R)-cis-2-(Boc-Amino)-1,2,3,4-Tetrahydro-1-Naphthol
CAS No.	904316-34-3
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.34 g/mol
Synonyms	(1S,2R)-2-[(tert-Butoxycarbonyl)amino]-1,2,3,4-tetrahydro-1-naphthalenol; (1S,2R)-2-(Boc-amino)-1,2,3,4-tetrahydro-1-naphthol; cis-2-(Boc-Amino)-1,2,3,4-tetrahydro-1-naphthol; (1S,2R)-cis-2-(tert-Butoxycarbonylamino)-1,2,3,4-tetrahydro-1-naphthol; tert-Butyl ((1S,2R)-1-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)carbamate; BOC-ATN; BOC-Amino-Tetralol derivative
EINECS	Contact for details

Quality Control

Our production of (1S,2R)-cis-2-(Boc-Amino)-1,2,3,4-Tetrahydro-1-Naphthol adheres to stringent quality protocols suitable for pharmaceutical R&D. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) are provided, detailing results from chiral HPLC, NMR, and mass spectrometry. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.