Description

(1R,2S)-cis-2-(Boc-Amino)-1,2,3,4-Tetrahydro-1-Naphthol is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, offering a protected amine group and a defined stereochemistry essential for constructing active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Serves as a crucial starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers.
• Peptidomimetics & PROTACs: Used in the construction of peptide-like molecules and Proteolysis-Targeting Chimeras (PROTACs) due to its rigid, fused-ring structure and protected amine.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Custom Synthesis: A valuable substrate for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis services.
• Academic Research: Used in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(1R,2S)-cis-2-(Boc-Amino)-1,2,3,4-Tetrahydro-1-Naphthol
CAS No.	904316-29-6
Molecular Formula	C16H21NO3
Molecular Weight	275.34 g/mol
Synonyms	(1R,2S)-2-[(tert-Butoxycarbonyl)amino]-1,2,3,4-tetrahydro-1-naphthalenol; (1R,2S)-cis-2-(Boc-Amino)-1,2,3,4-tetrahydro-1-naphthol; (1R,2S)-2-(Boc-amino)-1,2,3,4-tetrahydro-1-naphthol; tert-Butyl ((1R,2S)-1-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)carbamate; Boc-ATN; Boc-(1R,2S)-cis-2-Amino-1,2,3,4-tetrahydro-1-naphthol; (1R,2S)-cis-Boc-Amino Tetralol
EINECS	Contact for details

Quality Control

Our (1R,2S)-cis-2-(Boc-Amino)-1,2,3,4-Tetrahydro-1-Naphthol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.