Description

(1S,2S)-trans-2-(Boc-Amino)-1,2-Dihydro-1-Naphthol is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex, biologically active molecules, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing new therapeutic agents, particularly in areas requiring enantiomerically pure scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Asymmetric Synthesis: Serves as a versatile starting material or ligand precursor in catalytic asymmetric transformations to construct complex molecular architectures.
• Peptidomimetics & PROTACs Development: Used in the construction of peptide-like molecules and Proteolysis Targeting Chimeras (PROTACs) due to its protected amine and naphthol functionalities.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial-scale manufacturing of chiral drugs.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(1S,2S)-trans-2-(Boc-Amino)-1,2-Dihydro-1-Naphthol
CAS No.	904316-27-4
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.34 g/mol
Synonyms	(1S,2S)-2-[(tert-Butoxycarbonyl)amino]-1,2-dihydro-1-naphthol; (1S,2S)-2-(Boc-amino)-1,2-dihydronaphthalen-1-ol; tert-Butyl ((1S,2S)-1-hydroxy-1,2-dihydronaphthalen-2-yl)carbamate; trans-2-(N-Boc-amino)-1,2-dihydro-1-naphthol; Boc-ADHN; (1S,2S)-BocNH-DHN; N-Boc-1,2-dihydro-1,2-naphthalenediol amine derivative
EINECS	Contact for details

Quality Control

Our (1S,2S)-trans-2-(Boc-Amino)-1,2-Dihydro-1-Naphthol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.