Description

(1S)-1-Aminoindane-5-Carbonitrile is a chiral, non-racemic organic building block featuring an amino group and a nitrile functionality on an indane scaffold. This compound matters as a high-value, stereochemically defined intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of central nervous system (CNS) active drugs, enzyme inhibitors, and receptor modulators.
• Agrochemical Synthesis: Used in the creation of novel, optically active pesticides and herbicides with potentially improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags, affinity labels, and other molecular probes.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring high enantiomeric purity and reliable supply chain integrity.

Basic Information

Product Name	(1S)-1-Aminoindane-5-Carbonitrile
CAS No.	903630-35-3
Molecular Formula	C10H10N2
Molecular Weight	158.20 g/mol
Synonyms	(1S)-1-Amino-2,3-dihydro-1H-indene-5-carbonitrile; (S)-1-Aminoindane-5-carbonitrile; (S)-5-Cyano-1-aminoindane; 5-Cyano-1-indanamine, (1S)-; (1S)-5-Cyanoindan-1-amine; (S)-1-Amino-5-cyanoindane; (1S)-1-Amino-2,3-dihydro-1H-indene-5-carbonitrile; (S)-1-Amino-1,2,3,4-tetrahydro-5-cyanonaphthalene
EINECS	Contact for details

Quality Control

Our (1S)-1-Aminoindane-5-Carbonitrile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, to ensure compliance with exacting standards for research and development use. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.