Description

(S)-1-Amino-4-Methyl-2,3-Dihydro-1H-Indene-5-Carboxylic Acid Hydrochloride is a high-purity chiral building block essential for advanced pharmaceutical synthesis. This compound matters because it provides a structurally constrained, enantiomerically pure scaffold for developing novel active pharmaceutical ingredients (APIs) with improved efficacy and safety profiles. Pharmaceutical R&D and process chemistry teams need it for the synthesis of complex molecules targeting central nervous system (CNS) disorders, cardiovascular diseases, and other therapeutic areas where stereochemistry is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel small-molecule drug candidates.
• API Synthesis: Used in the construction of complex, stereochemically defined active pharmaceutical ingredients (APIs), particularly for CNS-targeting therapies.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to introduce chiral centers.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs due to its rigid, fused-ring indane structure.
• Peptidomimetic Development: The carboxylic acid and amino functionalities make it suitable for creating conformationally restricted peptide analogs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	(S)-1-Amino-4-Methyl-2,3-Dihydro-1H-Indene-5-Carboxylic Acid Hydrochloride
CAS No.	903557-53-9
Molecular Formula	C12H16ClNO2
Molecular Weight	241.71 g/mol
Synonyms	(1S)-1-Amino-4-methyl-2,3-dihydro-1H-indene-5-carboxylic acid hydrochloride; (S)-1-Amino-4-methylindane-5-carboxylic acid HCl; (S)-5-Carboxy-4-methylindan-1-amine hydrochloride; 4-Methyl-1-aminoindane-5-carboxylic acid hydrochloride (S-enantiomer); (S)-AMICA hydrochloride; 903557-53-9; (1S)-4-Methyl-1,2,3,4-tetrahydro-1-amino-5-isoindolecarboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1-Amino-4-Methyl-2,3-Dihydro-1H-Indene-5-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical R&D and scale-up. We provide comprehensive analytical data, including chiral purity verification by HPLC. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.