Description

(1R)-1-Aminoindane-5-Carbonitrile Hcl is a chiral amine derivative of indane, specifically the (R)-enantiomer, supplied as its hydrochloride salt. This compound serves as a critical pharmaceutical intermediate and chiral building block for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily utilized by research organizations and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular research.
• Chiral Building Block: Used in asymmetric synthesis to introduce the (R)-1-aminoindane moiety into complex molecular architectures.
• Agrochemical Research: Serves as a starting material for developing new pesticides and herbicides with specific stereochemical requirements.
• Ligand Synthesis: Potential precursor for creating chiral ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Used in the development of molecular probes for studying biological pathways and enzyme functions.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for commercial production of fine chemicals.

Basic Information

Product Name	(1R)-1-Aminoindane-5-Carbonitrile Hydrochloride
CAS No.	903556-00-3
Molecular Formula	C10H10N2·HCl
Molecular Weight	194.66 g/mol (Free base: 158.20 g/mol)
Synonyms	(R)-1-Aminoindane-5-carbonitrile hydrochloride; (1R)-1-Amino-2,3-dihydro-1H-indene-5-carbonitrile hydrochloride; (R)-1-Aminoindan-5-carbonitrile HCl; 5-Cyano-(1R)-1-aminoindane hydrochloride; (R)-5-Cyano-1-aminoindane hydrochloride; (R)-Aminoidan-5-carbonitril hydrochlorid; 1H-Indene-5-carbonitrile, 1-amino-2,3-dihydro-, (1R)-, hydrochloride
EINECS	Contact for details

Quality Control

Our (1R)-1-Aminoindane-5-Carbonitrile Hcl is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and enantiomeric excess (e.e.). Standard testing includes HPLC for assay and chiral purity, along with identification by IR and NMR. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.