Description

(R)-tert-Butyl (5-Cyano-2,3-Dihydro-1H-Inden-1-Yl)Carbamate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its role as a key building block for constructing complex, biologically active molecules with defined stereochemistry. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries, particularly for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and production of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Used in the construction of complex, enantiomerically pure molecules where the indane scaffold and cyano functionality are required.
• Process Chemistry & Scale-Up: Serves as a reliable starting material for process optimization and kilogram-to-ton scale manufacturing under GMP conditions.
• Protease Inhibitor Research: Potential building block in the development of protease inhibitors due to its specific stereochemistry and functional groups.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the discovery of new chemical entities (NCEs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high chiral purity.

Basic Information

Item	Detail
Product Name	(R)-tert-Butyl (5-Cyano-2,3-Dihydro-1H-Inden-1-Yl)Carbamate
CAS No.	903555-99-7
Molecular Formula	C15H18N2O2
Molecular Weight	258.32 g/mol
Synonyms	(1R)-1-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,3-dihydro-5-cyano-1H-indene; (R)-1-N-Boc-amino-5-cyanoindane; tert-Butyl (1R)-5-cyano-2,3-dihydro-1H-inden-1-ylcarbamate; (R)-1-Amino-5-cyanoindane N-Boc derivative; BOC-(R)-5-cyanoindanylamine; (R)-5-Cyano-1-indanyl N-Boc-carbamate
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl (5-Cyano-2,3-Dihydro-1H-Inden-1-Yl)Carbamate is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the exacting standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are available for every batch. Our quality commitment aligns with ICH guidelines, and we can support regulatory filings with relevant documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.