Description

tert-Butyl (5-Cyano-2,3-Dihydro-1H-Inden-1-Yl)Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected amine group and a cyano-substituted indane core. This compound is critical for the synthesis of complex bioactive molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers developing novel therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of active pharmaceutical ingredients (APIs), especially in oncology and CNS drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile indane scaffold and protected functional groups.
• Production of Kinase Inhibitors: A vital precursor in the synthetic pathways for various protein kinase inhibitors, a major class of targeted cancer therapies.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production of novel drug substances.
• Protecting Group Chemistry: The tert-butyloxycarbonyl (Boc) group allows for selective amine protection and deprotection in multi-step organic syntheses.
• Academic and Industrial R&D: Employed in research institutions and corporate R&D departments for exploratory chemistry and new molecular entity development.

Basic Information

Product Name	tert-Butyl (5-Cyano-2,3-Dihydro-1H-Inden-1-Yl)Carbamate
CAS No.	903555-96-4
Molecular Formula	C15H18N2O2
Molecular Weight	258.32 g/mol
Synonyms	1H-Indene-1-carboxamide, 5-cyano-2,3-dihydro-N-[(1,1-dimethylethoxy)carbonyl]-; 1-Boc-5-cyanoindane; 1-N-Boc-amino-5-cyanoindane; 5-Cyano-2,3-dihydro-1H-inden-1-yl-carbamic acid tert-butyl ester; tert-Butyl 5-cyano-2,3-dihydro-1H-indene-1-carbamate; 5-Cyanoindan-1-yl-carbamic acid tert-butyl ester; Boc-5-cyanoindoline (common misnomer); 903555-96-4
EINECS	Contact for details

Quality Control

Our tert-Butyl (5-Cyano-2,3-Dihydro-1H-Inden-1-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to ISO 9001 standards, and we support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.