Description

Desmethyl Ferroquine is a key synthetic intermediate and metabolite of the antimalarial ferroquine. This compound is of significant interest for pharmaceutical research and development, particularly in the study of antimalarial drug metabolism, mechanism of action, and the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in antimalarial drug discovery and advanced chemical synthesis.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug substance and product testing.
• Metabolite Studies: Critical for in vitro and in vivo pharmacokinetic and pharmacodynamic (PK/PD) studies to understand the biotransformation and activity of ferroquine.
• Chemical Intermediate: Serves as a sophisticated building block for the synthesis of novel ferroquine analogs and related organometallic compounds with potential therapeutic applications.
• Mechanistic Research: Employed in biochemical and parasitological assays to investigate the mode of action and resistance mechanisms against Plasmodium species.
• Impurity Profiling: Essential for identifying and quantifying process-related impurities and degradation products in ferroquine active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Desmethyl Ferroquine
CAS No.	903546-18-9
Molecular Formula	C₂₀H₂₃ClFeN₂
Molecular Weight	382.70 g/mol
Synonyms	7-Chloro-4-[[(2-ferrocenyl-1-ethyl)amino]methyl]quinoline; N-[(7-Chloro-4-quinolinyl)methyl]-N'-(2-ferrocenylethyl)-1,2-ethanediamine (Desmethyl); SSR97213; Ferroquine Metabolite M1; 1-{2-[(7-Chloro-4-quinolinyl)methylamino]ethyl}ferrocene
EINECS	Contact for details

Quality Control

Our Desmethyl Ferroquine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications. We support cGMP standards for advanced intermediates used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.