Description

tert-Butyl 2,4-Dichloro-5H-Pyrrolo[3,4-D]Pyrimidine-6(7H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its fused pyrrolopyrimidine heterocyclic structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for oncology and antiviral drug candidates.
• Kinase Inhibitor Development: Serves as a core scaffold for constructing potent and selective kinase inhibitors due to its privileged pyrrolopyrimidine structure.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for custom synthesis projects and scale-up activities.
• Biochemical Tool Compound: May be utilized in biochemical assays to study enzyme mechanisms and cellular pathways.

Basic Information

Product Name	tert-Butyl 2,4-Dichloro-5H-Pyrrolo[3,4-D]Pyrimidine-6(7H)-Carboxylate
CAS No.	903129-71-5
Molecular Formula	C11H11Cl2N3O2
Molecular Weight	288.13 g/mol
Synonyms	2,4-Dichloro-6-(tert-butoxycarbonyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine; tert-Butyl 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-6-carboxylate; 6-(tert-Butoxycarbonyl)-2,4-dichloro-5,6,7,8-tetrahydropyrrolo[3,4-d]pyrimidine; 2,4-Dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylic acid tert-butyl ester; BOC-2,4-Dichloropyrrolopyrimidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,4-Dichloro-5H-Pyrrolo[3,4-D]Pyrimidine-6(7H)-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.