Description

n-Boc-3-Amino-1,2,3,4-Tetrahydro-Naphthalene-2-Carboxylic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block for the construction of complex pharmaceutical intermediates and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders and other therapeutic areas.
• Peptidomimetics & Constrained Peptides: Used to introduce a rigid, hydrophobic tetralin scaffold into peptide backbones to enhance metabolic stability and receptor selectivity.
• Medicinal Chemistry Research: Serves as a versatile building block in combinatorial chemistry and library synthesis for structure-activity relationship (SAR) studies.
• Process Chemistry Development: Employed in the scalable, multi-step synthesis of complex drug candidates, leveraging its Boc-protected amine for selective deprotection.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective reactions to create enantiomerically pure compounds.

Basic Information

Product Name	n-Boc-3-Amino-1,2,3,4-Tetrahydro-Naphthalene-2-Carboxylic Acid
CAS No.	903094-83-7
Molecular Formula	C₁₆H₂₁NO₄
Molecular Weight	291.34 g/mol
Synonyms	3-[(tert-Butoxycarbonyl)amino]-1,2,3,4-tetrahydro-2-naphthoic acid; 2-Naphthalenecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,4-tetrahydro-; Boc-3-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic Acid; (3-{[(tert-Butoxy)carbonyl]amino}-1,2,3,4-tetrahydronaphthalen-2-yl)carboxylic Acid; tert-Butyl (2-carboxy-1,2,3,4-tetrahydronaphthalen-3-yl)carbamate; Boc-Amino-Tetralin-Carboxylic Acid
EINECS	Contact for details

Quality Control

Our n-Boc-3-Amino-1,2,3,4-Tetrahydro-Naphthalene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.