Description

3-tert-Butoxycarbonylamino-3-Cyclobutyl-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a cyclobutyl side chain and a Boc-protected amine group. This compound serves as a critical chiral building block for the synthesis of complex, biologically active molecules, offering precise control over stereochemistry and molecular architecture. It is primarily utilized by pharmaceutical R&D and process chemistry teams for the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel drug candidates, particularly in oncology, neurology, and metabolic disease research.
• Peptidomimetics & Constrained Peptides: Used to introduce the rigid, three-dimensional cyclobutyl ring into peptide backbones, enhancing metabolic stability and binding affinity.
• Protease Inhibitor Development: Employed in constructing pharmacophores for inhibitors targeting various protease enzymes.
• Chemical Biology & Probe Synthesis: Serves as a building block for creating tool compounds and molecular probes to study biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects under cGMP guidelines.
• Academic Research: Used in university and institutional labs for methodological development in asymmetric synthesis and medicinal chemistry.

Basic Information

Product Name	3-tert-Butoxycarbonylamino-3-Cyclobutyl-Propionic Acid
CAS No.	903094-78-0
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	3-((tert-Butoxycarbonyl)amino)-3-cyclobutylpropanoic Acid; Boc-3-Cyclobutyl-β-alanine; (3-Cyclobutyl-3-{[(2-methylpropan-2-yl)oxycarbonyl]amino}propanoic Acid); 3-Cyclobutyl-3-[(tert-butoxycarbonyl)amino]propionic Acid; N-Boc-3-amino-3-cyclobutylpropionic Acid; 3-(Boc-amino)-3-cyclobutylpropanoic Acid; (R/S)-3-(tert-Butoxycarbonylamino)-3-cyclobutyl-propionic Acid (racemic mixture); 903094-78-0
EINECS	Contact for details

Quality Control

Our 3-tert-Butoxycarbonylamino-3-Cyclobutyl-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. Comprehensive Certificates of Analysis (COA) with full analytical data are provided with every shipment. We support development with custom purity grades and can supply material suitable for use under ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.