Description

1-(1-tert-Butoxycarbonyl-Pyrrolidin-3-Yl)-Piperidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a complex bicyclic amine structure protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex molecules targeting neurological and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly in central nervous system (CNS) and receptor-targeted therapies.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Peptidomimetic Synthesis: The constrained piperidine-pyrrolidine core structure makes it valuable for designing and synthesizing peptide mimics with enhanced metabolic stability.
• Ligand and Probe Development: Employed in the creation of specialized chemical probes and high-affinity ligands for biological target validation and assay development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials.
• Academic Research: Used in university and institutional labs for advanced studies in organic synthesis methodology and bioorganic chemistry.

Basic Information

Product Name	1-(1-tert-Butoxycarbonyl-Pyrrolidin-3-Yl)-Piperidine-3-Carboxylic Acid
CAS No.	903094-72-4
Molecular Formula	C15H26N2O4
Molecular Weight	298.38 g/mol
Synonyms	1-(1-Boc-Pyrrolidin-3-yl)piperidine-3-carboxylic acid; 1-[1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidin-3-yl]piperidine-3-carboxylic acid; 3-Carboxy-1-(1-N-Boc-3-pyrrolidinyl)piperidine; 1-(1-tert-Butoxycarbonylpyrrolidin-3-yl)piperidine-3-carboxylic Acid; Boc-Protected Pyrrolidinylpiperidine Carboxylic Acid; 903094-72-4; tert-Butyl 3-(3-carboxypiperidin-1-yl)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 1-(1-tert-Butoxycarbonyl-Pyrrolidin-3-Yl)-Piperidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP requirements. Specifications can be tailored to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.