Description

5-tert-Butoxycarbonylamino-Piperidine-3-Carboxylic Acid Methyl Ester is a high-purity, protected piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules with precise stereochemistry, essential for developing bioactive compounds. This intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on creating new active pharmaceutical ingredients (APIs), particularly in therapeutic areas like neurology and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Chemistry: Used in the design and construction of peptide analogs and constrained scaffolds to modulate biological activity.
• Medicinal Chemistry Research: Serves as a versatile building block for creating focused libraries and exploring structure-activity relationships (SAR).
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce the piperidine moiety with high enantiomeric purity.
• Protease Inhibitor Development: A potential precursor in the synthesis of inhibitors targeting various protease enzymes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	5-tert-Butoxycarbonylamino-Piperidine-3-Carboxylic Acid Methyl Ester
CAS No.	903094-67-7
Molecular Formula	C13H24N2O4
Molecular Weight	272.34 g/mol
Synonyms	5-((tert-Butoxycarbonyl)amino)piperidine-3-carboxylic acid methyl ester; Methyl 5-((tert-butoxycarbonyl)amino)piperidine-3-carboxylate; 5-(Boc-amino)piperidine-3-carboxylic acid methyl ester; Boc-5-amino-3-piperidinecarboxylic acid methyl ester; 3-Piperidinecarboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester; 903094-67-7; tert-Butyl 5-(methoxycarbonyl)-3-piperidinylcarbamate
EINECS	Contact for details

Quality Control

Our 5-tert-Butoxycarbonylamino-Piperidine-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.