Description

1-Boc-4-(Methoxycarbonyl)Pyrrolidine-3-Carboxylic Acid is a high-purity, multifunctional pyrrolidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected amine and multiple functional handles for the controlled construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Peptidomimetics & Constrained Peptide Design: Used to introduce rigid, functionalized pyrrolidine scaffolds that mimic peptide backbones, enhancing metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor for creating novel herbicides, fungicides, and insecticides with specific chiral centers.
• Ligand & Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring precise stereochemistry and functional group manipulation.

Basic Information

Product Name	1-Boc-4-(Methoxycarbonyl)Pyrrolidine-3-Carboxylic Acid
CAS No.	902835-87-4
Molecular Formula	C13H21NO6
Molecular Weight	287.31 g/mol
Synonyms	3-Carboxy-1-Boc-4-(methoxycarbonyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-4-(methoxycarbonyl)pyrrolidine-3-carboxylic Acid; 1-Boc-4-(carbonethoxypyrrolidine-3-carboxylic Acid; Pyrrolidine-3-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-4-(methoxycarbonyl)-; tert-Butyl 4-(methoxycarbonyl)-3-carboxypyrrolidine-1-carboxylate; Boc-4-(COOMe)-Pyrrolidine-3-COOH
EINECS	Contact for details

Quality Control

Our production of 1-Boc-4-(Methoxycarbonyl)Pyrrolidine-3-Carboxylic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against established specifications using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.