Description

4-(3-Carboxy-Pyridin-2-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with a protected carboxylic acid group and a pyridine moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up API synthesis under Good Manufacturing Practice (GMP) conditions.
• Protease Inhibitor Synthesis: The structural motifs present are valuable for constructing protease inhibitor scaffolds.
• Ligand Synthesis for Metal Complexes: The pyridine and carboxylate groups can act as chelating agents for creating catalysts or diagnostic agents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-(3-Carboxy-Pyridin-2-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	902835-85-2
Molecular Formula	C16H21N3O4
Molecular Weight	319.36 g/mol
Synonyms	2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)nicotinic acid; tert-Butyl 4-(3-carboxypyridin-2-yl)piperazine-1-carboxylate; 4-(3-Carboxy-2-pyridyl)piperazine-1-carboxylic acid tert-butyl ester; BOC-Piperazine-Nicotinic Acid Derivative; 902835-85-2; 2-(1-Boc-piperazin-4-yl)nicotinic acid; Nicotinic acid, 2-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]-
EINECS	Contact for details

Quality Control

Our 4-(3-Carboxy-Pyridin-2-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with ICH guidelines for impurities and can provide material for regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.