Description

(2''R)-N2''-Deacetyl-N2''-[4-Methyl-4-(Methyldithio)-1-Oxopentyl]-Maytansine is a highly potent and structurally defined maytansinoid derivative, a critical class of compounds used as payloads in antibody-drug conjugates (ADCs). Its value lies in its engineered chemical linker and potent cytotoxic activity, enabling the targeted delivery of therapeutic agents to specific cancer cells. This compound is essential for pharmaceutical R&D and manufacturing teams focused on developing next-generation oncology therapeutics, particularly in the ADC and targeted chemotherapy space.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic warhead chemically linked to monoclonal antibodies for targeted cancer therapy.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for novel cancer treatments.
• Bioconjugation Chemistry: Employed in studies to develop and optimize novel linker technologies for stable and effective drug-antibody conjugation.
• Mechanistic Studies: Utilized to investigate the mechanism of action of maytansinoids, including tubulin inhibition and apoptosis induction.
• Process Development: Critical for scaling up synthesis and purification processes in cGMP manufacturing environments for advanced therapeutics.

Basic Information

Product Name	(2''R)-N2''-Deacetyl-N2''-[4-Methyl-4-(Methyldithio)-1-Oxopentyl]-Maytansine
CAS No.	902768-55-2
Molecular Formula	C37H51ClN4O9S2
Molecular Weight	795.45 g/mol
Synonyms	DM4-SPDB; Maytansinoid DM4; N2'-Deacetyl-N2'-(4-methyl-4-(3-thiopropanoylthio)-1-oxopentyl)-maytansine; (2'R)-N(2')-Deacetyl-N(2')-[4-methyl-4-[(3-thiopropanoyl)thio]-1-oxopentyl]maytansine; DM4; SPDB-DM4; Ansamitocin P-3 derivative
EINECS	Contact for details

Quality Control

Our (2''R)-N2''-Deacetyl-N2''-[4-Methyl-4-(Methyldithio)-1-Oxopentyl]-Maytansine is manufactured under strict quality systems suitable for pharmaceutical development. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for research and pre-clinical use. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity	≤ 2.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.