Description

tert-Butyl [1-(Trifluoromethyl)Cyclopropyl]Carbamate is a high-value, multifunctional building block in advanced organic synthesis. Its core value lies in the unique combination of a sterically hindered tert-butyloxycarbonyl (Boc) protecting group and a trifluoromethylated cyclopropane ring, offering exceptional versatility for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for introducing the metabolically stable trifluoromethylcyclopropyl moiety into target molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics where the trifluoromethylcyclopropyl group enhances metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the incorporation of the fluorine-containing cyclopropane ring can improve biological activity and environmental persistence.
• Material Science Precursor: Serves as a specialty monomer or precursor for synthesizing fluorinated polymers and advanced materials with unique surface properties, chemical resistance, or optical characteristics.
• Medicinal Chemistry & Drug Discovery: Employed in high-throughput screening libraries and parallel synthesis for lead optimization and structure-activity relationship (SAR) studies, enabling rapid exploration of chemical space.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis organizations (CSOs) and CDMOs producing tailored intermediates for client-specific R&D and scale-up projects.

Basic Information

Product Name	tert-Butyl [1-(Trifluoromethyl)Cyclopropyl]Carbamate
CAS No.	902494-31-9
Molecular Formula	C9H14F3NO2
Molecular Weight	225.21 g/mol
Synonyms	1-(Trifluoromethyl)cyclopropanecarboxylic acid tert-butylamide; Boc-1-(Trifluoromethyl)cyclopropylamine; N-Boc-1-(trifluoromethyl)cyclopropanamine; tert-Butyl 1-(trifluoromethyl)cyclopropylcarbamate; 1-(Trifluoromethyl)cyclopropylamine N-Boc protected; N-(tert-Butoxycarbonyl)-1-(trifluoromethyl)cyclopropanamine; (1-(Trifluoromethyl)cyclopropyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl [1-(Trifluoromethyl)Cyclopropyl]Carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.