Description

n-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H-Pyrazole-3-Carboxamide Hydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant importance in modern pharmaceutical research and development. This compound is critical for the synthesis of advanced antiviral agents, offering a key building block for drug discovery programs targeting HIV and other retroviral infections. It is primarily sought by pharmaceutical R&D laboratories, biotechnology firms, and fine chemical manufacturers engaged in the development of next-generation therapeutic compounds.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral therapies.
• Antiviral Drug Research: Used as a key scaffold and building block in medicinal chemistry programs focused on HIV-1 and other retroviral targets.
• Biochemical Research: Employed in biochemical assays and studies to understand enzyme inhibition mechanisms and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing specialized active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	n-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H-Pyrazole-3-Carboxamide Hydrochloride
CAS No.	902135-91-5
Molecular Formula	C16H17Cl2N5O2 • HCl
Molecular Weight	424.71 g/mol
Synonyms	4-[(2,6-Dichlorobenzoyl)amino]-N-(4-piperidinyl)-1H-pyrazole-3-carboxamide hydrochloride; R221239 Hydrochloride; 1H-Pyrazole-3-carboxamide, 4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl-, hydrochloride (1:1); NNRTI Intermediate R221239 HCl; 902135-91-5; 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide hydrochloride
EINECS	Contact for details

Quality Control

Our n-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H-Pyrazole-3-Carboxamide HCl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable material for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.