Description

1-[3-(Trifluoromethyl)Benzyl]Piperidine-4-Carboxylic Acid is a high-value trifluoromethylated piperidine derivative, serving as a critical building block in modern organic synthesis. Its core value lies in the unique combination of the piperidine scaffold and the trifluoromethyl group, which are instrumental in modulating the physicochemical and pharmacokinetic properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of central nervous system (CNS) active drugs, enzyme inhibitors, and receptor modulators.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Chemical Biology Probe Synthesis: Employed in constructing molecular probes for studying biological pathways and target engagement.
• Material Science Precursor: Acts as a starting material for specialty polymers and advanced organic materials with tailored properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	1-[3-(Trifluoromethyl)Benzyl]Piperidine-4-Carboxylic Acid
CAS No.	901920-52-3
Molecular Formula	C14H16F3NO2
Molecular Weight	287.28 g/mol
Synonyms	1-[(3-Trifluoromethyl)phenyl]methyl-4-piperidinecarboxylic acid; 4-Piperidinecarboxylic acid, 1-[[3-(trifluoromethyl)phenyl]methyl]-; 1-[(3-Trifluoromethyl)benzyl]isonipecotic acid; 3-(Trifluoromethyl)benzyl isonipecotate precursor; α,α,α-Trifluoro-m-tolylmethyl isonipecotate; 1-(3-Trifluorobenzyl)piperidine-4-carboxylic acid; 1-(3-(Trifluoromethyl)benzyl)piperidine-4-carboxylic acid; 901920-52-3
EINECS	Contact for details

Quality Control

Our 1-[3-(Trifluoromethyl)Benzyl]Piperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent absorption of atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.