Description

(5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-[Methyl(Methylsulfonyl)Amino]-5-Pyrimidinyl]-5-Hydroxy-3-Oxo-6-Heptenoic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex molecular architecture. This compound is of significant value for its role as a key synthetic precursor in the development of novel therapeutic agents, particularly in the field of metabolic and inflammatory disease research. It is primarily required by pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of proprietary drug candidates targeting specific biological pathways.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in API manufacturing.
• Biochemical Research: Utilized as a tool compound in biochemical assays to study enzyme inhibition or receptor modulation.
• Custom Synthesis: Acts as a starting material for the contract synthesis of more complex, tailored molecules for client-specific research projects.

Basic Information

Product Name	(5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-[Methyl(Methylsulfonyl)Amino]-5-Pyrimidinyl]-5-Hydroxy-3-Oxo-6-Heptenoic Acid Ethyl Ester
CAS No.	901765-36-4
Molecular Formula	C26H32FN3O6S
Molecular Weight	533.61 g/mol
Synonyms	Ethyl (5S,6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-5-hydroxy-3-oxohept-6-enoate; (5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethanesulfonamido)pyrimidin-5-yl]-5-hydroxy-3-oxo-6-heptenoic acid ethyl ester; A key Montelukast intermediate; Montelukast advanced intermediate; 5-Hydroxy-3-oxo-6-heptenoic acid ethyl ester derivative; 4-(4-Fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]pyrimidin-5-yl substituted heptenoate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data to support your regulatory and development needs. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.