Description

1-Benzyloxy-4-Bromo-2,5-Difluorobenzene is a high-purity, multi-functional halogenated aromatic ether building block. This compound is valued for its unique substitution pattern, which makes it a critical intermediate in advanced organic synthesis, particularly for constructing complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications in cross-coupling reactions and as a precursor to active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those requiring difluorobenzene and bromoaryl motifs for Suzuki, Buchwald-Hartwig, or other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and pesticides, where the fluorine and bromine atoms contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for the synthesis of fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Employed as a monomer or modifier in the production of specialty polymers and high-performance resins with tailored thermal and chemical properties.
• Chemical Research & Development: An essential reagent for academic and industrial research exploring new synthetic methodologies and creating compound libraries for screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	1-Benzyloxy-4-Bromo-2,5-Difluorobenzene
CAS No.	901238-24-2
Molecular Formula	C13H9BrF2O
Molecular Weight	299.11 g/mol
Synonyms	4-Bromo-2,5-difluorophenyl benzyl ether; Benzyl 4-bromo-2,5-difluorophenyl ether; 1-Bromo-4-(benzyloxy)-2,5-difluorobenzene; 2,5-Difluoro-4-bromophenyl benzyl ether; 901238-24-2; 4-Bromo-2,5-difluoro-1-(phenylmethoxy)benzene
EINECS	Contact for details

Quality Control

Our 1-Benzyloxy-4-Bromo-2,5-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.