Description

(αs,γs)-4-Methoxy-3-(3-Methoxypropoxy)-γ-(1-Methylethyl)-α-[[(Phenylmethoxy)Carbonyl]Amino]Benzenepentanoic Acid Methyl Ester is a high-purity, non-racemic chiral compound that serves as a critical advanced intermediate in modern pharmaceutical synthesis. Its complex, functionalized structure makes it a valuable building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of proprietary drug candidates, especially for central nervous system (CNS) or metabolic disease targets.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale production for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis Research: Serves as a sophisticated substrate or precursor in academic and industrial research focused on developing new stereoselective reactions.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control during API manufacturing.
• Custom Synthesis Building Block: Utilized by fine chemical suppliers to construct more complex molecular architectures for client-specific projects.

Basic Information

Product Name	(αs,γs)-4-Methoxy-3-(3-Methoxypropoxy)-γ-(1-Methylethyl)-α-[[(Phenylmethoxy)Carbonyl]Amino]Benzenepentanoic Acid Methyl Ester
CAS No.	900811-40-7
Molecular Formula	C27H37NO7
Molecular Weight	487.59 g/mol
Synonyms	Methyl (2S,4S)-5-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoate; (2S,4S)-Methyl 5-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoate; (2S,4S)-Z-AMB-Methyl Ester; Z-Protected AMB Ester Intermediate; Chiral Benzenepentanoic Acid Ester Derivative; (S,S)-Diastereomer of C27H37NO7; API Intermediate 900811-40-7
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical development. Each batch is characterized and released with a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Quality is assured through analytical methods including HPLC, chiral HPLC, GC, and NMR to confirm stereochemical purity and chemical identity. We support development under GMP guidelines for critical applications, ensuring traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (Diastereomeric excess)
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.